Among other File Formats, the Huygens Software reads and writes TIFF series with Leica style numbering if there are multiple channels (different wavelength), slices or frames (in a Time Series). The File Series Tool can be used to load any type of Tiff series, including Leica Tiff series.
An image of four slices and two frames is named with Leica style numbering as follows:
c_t00_z000.tif c_t00_z001.tif c_t00_z002.tif c_t00_z003.tif c_t01_z000.tif c_t01_z001.tif c_t01_z002.tif c_t01_z003.tif
And an image sTCh of four slices, three frames and two channels:
sTCh_t00_z000_ch00.tif sTCh_t00_z000_ch01.tif sTCh_t00_z001_ch00.tif sTCh_t00_z001_ch01.tif sTCh_t00_z002_ch00.tif sTCh_t00_z002_ch01.tif sTCh_t00_z003_ch00.tif sTCh_t00_z003_ch01.tif sTCh_t01_z000_ch00.tif sTCh_t01_z000_ch01.tif sTCh_t01_z001_ch00.tif sTCh_t01_z001_ch01.tif sTCh_t01_z002_ch00.tif sTCh_t01_z002_ch01.tif sTCh_t01_z003_ch00.tif sTCh_t01_z003_ch01.tif sTCh_t02_z000_ch00.tif sTCh_t02_z000_ch01.tif sTCh_t02_z001_ch00.tif sTCh_t02_z001_ch01.tif sTCh_t02_z002_ch00.tif sTCh_t02_z002_ch01.tif sTCh_t02_z003_ch00.tif sTCh_t02_z003_ch01.tif
If your TIFF series doesn't follow this supported convention, you may be interested in Renaming Tiff Series easily.
Important for Ratiometric Images: see Tiff Scaling.